The Advanced Drug Delivery Research (ADDRES) Laboratory at Northeastern
University is headed by Dr. Rebecca Carrier of Northeastern’s
Department of Chemical Engineering.
The ADDRES Lab studies interactions between materials and biological systems,
with a current focus on the intestinal environment, via development of
theoretical and tissue-engineered cell culture models. Computational models
(molecular and macroscopic) predict what drug delivery systems will enhance
absorption of a compound with specific physical and chemical properties.
Macroscopic systems-based models of the intestinal drug delivery environment
are in the form of mass balances and kinetic equations describing drug
release, dissolution, precipitation, and absorption. Mechanistic studies are
conducted to enhance fundamental understanding of these processes. Our tissue
engineering focus is on developing a biomimetic scaffold with crypt-villus
structure for intestinal epithelial cell culture.