Publications

Papers

Gamsiz, D.E, Thombre, A., Miller, L.A, Carrier, R.L., Modeling the influence of cyclodextrins on oral absorption of insoluble drugs: 1. Model Development, Biotechnology & Bioengineering, In press. .pdf

Gamsiz, D.E, Thombre, A., Miller, L.A, Carrier, R.L., Modeling the influence of cyclodextrins on oral absorption of insoluble drugs: 2. Model Validation, Biotechnology & Bioengineering, In Press. .pdf

Buyukozturk, Fulden; Benneyan, James C.; Carrier, Rebecca L., Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics, Jouranl of Controlled Release, In press. .pdf

Wang, Lin; Murthy, Shashi K.; Fowle, William H.; Barabino, Gilda A.; Carrier, Rebecca L., Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype, Biomaterials (2009), 30(36), 6825-6834. .pdf

Wang, Lin; Sun, Bing; Ziemer, Katherine S.; Barabino, Gilda A.; Carrier, Rebecca L., Chemical and physical modifications to poly(dimethylsiloxane) surfaces affect adhesion of Caco-2 cells, Journal of Biomedical Materials Research, Part A, In Press .pdf

Wang, L., Nagesha, D. K., Selvarasah, S., Dokmeci, M. R., and Carrier, R. L. 2008. Toxicity of CdSe nanoparticles in Caco-2 cell cultures. J. Nanobiotechnology. .pdf 
 
Gamsiz, D. E., Shah, L. K., Devalapally, H., Amiji, M. M. and Carrier, R. L. 2008. A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells. Biotechnol. and Bioeng., 101(5), 1072-1082. .pdf 
 
Carrier, R. L., Miller, L. A., and Ahmed, I. 2007. The utility of cyclodextrins for enhancing oral bioavailability. J. Controlled Release. 123: 78-99. .pdf 
 
Miller, L. A., Carrier, R. L., and Ahmed, I. 2007. Practical considerations in development of solid dosage forms that contain cyclodextrin. J. Pharm. Sci. 96(7): 1691-1707. .pdf 
 
Carrier, R. L., Waterman, K. Utility of biodegradable polymers in oral drug delivery, in "Handbook of Biodegradable Polymeric Materials and Their Applications," edited Mallapragada, S. K., Narasimhan, B, American Scientific Publishers, 2006.  
 
Bueno, E. M., Bilgen, B., Carrier, R. L., Barabino, G. A. 2004. Increased rate of chondrocyte aggregation in a wavy-walled bioreactor. Biotechnol. and Bioeng. 88(6): 767-777. .pdf 
 
Carrier, R. L., Rupnick, M., Langer, R., Schoen, F. J., Freed, L. E., Vunjak-Novakovic, G. 2002. Effects of oxygen on engineered cardiac muscle. Biotechnol. and Bioeng. 78(6): 616-624. .pdf 
 
Carrier, R. L., Rupnick, M., Langer, R., Schoen, F. J., Freed, L. E., Vunjak-Novakovic, G. 2002. Perfusion improves architecture of engineered cardiac muscle. Tissue Eng. 8(2): 175-188. .pdf 
 
Waterman, K. D., Adami, R. C., Alsante, K. M., Antipas, A. S., Arenson, D. R., Carrier, R., Hong, J., Landis, M. S., Lombardo, F., Shah, J. C., Shalaev, E., Smith, S. W., Wang, H. 2002. Hydrolysis in pharmaceutical formulations. Pharm. Dev. Technol. 7(2): 113-146. .pdf

Carrier, R. L., Papadaki, M., Rupnick, M., Schoen, F. J., Bursac, N., Langer, R., Freed, L. E., Vunjak-Novakovic, G. 1999. Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. Biotechnol. Bioeng. 64: 580-589. .pdf 
 
Obradovic, B., Carrier, R. L, Vunjak-Novakovic, G., Freed, L. E. 1999. Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage. Biotechnol. Bioeng. 63: 197-205. .pdf 
 
Bursac, N., Papadaki, M., Cohen, R. J., Schoen, F. J., Eisenberg, S. R., Carrier, R. L., Vunjak-Novakovic, G., Freed, L. E. 1999. Cardiac muscle tissue engineering: towards an in vitro model for electrophysiological studies. Am. J. Physiol. 277(2, Pt 2): H433-H444. .pdf

top

Presentations

Gamsiz, D.E, Miller, L. Thombre, A., Carrier, R.L.,"Development of a computer program predicting the influence of cyclodextrins on oral bioavailability of insoluble drugs: From modeling to in vivo comparison," American Institute of Chemical Engineers Annual Meeting, Salt Lake City, UT, November 2007.

Pfluger, C., Carrier, R. L., Burkey D. D. "Nano and micro scale replication of the intestinal basement membrane using chemical vapor deposition," American Institute of Chemical Engineers 2007 National Meeting, Salt Lake City, UT, November 2007.

Gamsiz, D.E, Miller, L. Thombre, A., Carrier, R.L. "Model Prediction of the Influence of Cyclodextrins on Oral Bioavailability of Insoluble Drugs," ISPE Annual Meeting, Las Vegas, NV, November 2007.

Wang, L., Murthy, S. K., Carrier, R. L. "Intestinal epithelial cell response to crypt-like substrate topography," American Chemical Society 234th National Meeting, Boston, MA, August, 2007.

Gamsiz, D.E., Shah, L., Amiji, M., Carrier, R.L "A Model Predicting Delivery of Saquinavir in Nanoparticles to Human Monocyte/Macrophage (Mo/Mac) Cells" presented at 234th American Chemical Society, 234th National Meeting, Boston, MA, August, 2007.

Sadasivan, V. D., Sacco, A., Jr., Budil, D. E., Gulla, S., Carrier, R. L. "Studying the human intestinal mucin (MUC2) using molecular modeling approaches for drug transport study," American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November, 2006.

Wang, L., Murthy, S., Dokmeci, M., Carrier, R. L. "Chemical and topographical modification to polydimethylsiloxane (PDMS) surfaces affect growth and adhesion of Caco-2 cells," American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November, 2006.

Bhardwaj, S., Gamsiz, E. D., Carrier, R. L. "Physiological modeling of gastrointestinal tract for predicting the effect of cyclodextrin on bioavailability of neutral compounds," American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November, 2006.

Gamsiz, E. D., Miller, L. A, Thombre, A. G. Carrier, R. L. "Validation of a model predicting the influence of cyclodextrins on oral bioavailability: Comparison with in vitro and in vivo data," American Institute of Chemical Engineers Annual Meeting, San Francisco, CA, November, 2006.

Shah, L. K., Gamsiz, E. D., Carrier, R. L., Amiji, M. M. "Biodegradable polymeric nanoparticles for intracellular saquinavir delivery in HIV/AIDS," 2006 AAPS Annual Meeting and Exposition, San Antonio, TX, November, 2006.

Wang, L., Murthy, S., Carrier, R. L. "Effect of cell culture substrate topology on Caco-2 cell growth and attachment," poster presentation at the 1st Annual Methods in Bioengineering Conference, Cambridge, MA, July 2006.

Gamsiz, D. E., Miller, L. A., Thombre, A., Carrier, R. "Modeling the influence of cyclodextrins on oral absorption of neutral and saltform drugs delivered as a pre-formed complex," poster presentation at the 2006 AAPS National Biotechnology Conference, Boston, MA, June 2006.

Sadasivan, V. Budil, D. Sacco, A. Jr., Carrier, R. "Structural Prediction of the Carbon Terminal End of Human Intestinal Mucin (MUC2) Using Molecular Modeling," 2006 NSTI Nanotechnology Conference and Trade Show, Boston, MA, May 2006.

Sadasivan, V., Budil, D., Sacco, A. Jr., Carrier, R. "Molecular modeling of the C-terminal end of human intestinal mucin (MUC2) predicts a cysteine-knot tertiary structure," 231st ACS National Meeting, Atlanta, GA, March 2006.

Gamsiz, D. E., Thombre, A. G., Miller, L. A., Carrier, R. L., "Modeling the influence of cyclodextrins on oral absorption of saltform drug in immediate and controlled release delivery," presented at the American Institute of Chemical Engineers Annual Meeting, Cincinnati, OH, November 2005.

Gamsiz, D. E., Miller, L. A., Thombre, A. G., Carrier, R. L., "Predicting the ability of cyclodextrin to enhance intestinal absorption in controlled release delivery: Comparison with immediate release," presented at the Controlled Release Society Annual Meeting, Miami, FL, June 2005.

Wang, L., Dokmeci, M. R., Barabino, G. and Carrier, R. L. "Chemical and microstructural design of poly(dimethylsiloxane) substrate for tissue engineered intestine ," poster presentation at 2nd International Conference on Tissue Engineering, Crete, Greece, May 2005.

Gamsiz, D. E., Miller, L. A., Ahmed, I., Thombre, A. G., Carrier, R. L., "Mathematical model for enhanced drug transport across intestinal mucosa using cyclodextrins," presented at the American Institute of Chemical Engineers Annual Meeting, Austin, TX, November 2004.

Carrier, R. L., Freed, L. E., Schoen, F. J., Rupnick, M., Langer, R., and Vunjak-Novakovic, G. "Control of the structure and metabolism of engineered cardiac muscle by direct perfusion of culture medium," presented at the American Chemical Society Meeting, San Francisco, CA, March 2000. Carrier, R. L., Freed, L. E., Schoen, F. J., Rupnick, M., Langer, R., and Vunjak-Novakovic, G.

"Oxygen and hydrodynamics influence protein expression and metabolism in engineered cardiac muscle," poster presentation at the International Society for Applied Cardiovascular Biology Meeting, Tucson, AZ, March 2000.

Carrier, R. L., Bursac, N., Papadaki, M., Langer, R., Vunjak-Novakovic, G., and Freed, L. E. "Bioreactor design affects the structural, biochemical, and metabolic properties of engineered cardiac tissue," poster presentation at the American Institute of Chemical Engineers Meeting, Miami, FL, November 1998.

Carrier, R. L., Bursac, N., Vunjak-Novakovic, G., Langer, R., Rupnick, M. A., and Freed, L. E. "Development of a model culture system for cardiac tissue engineering: Investigation of key parameters," presented at the American Institute of Chemical Engineers Meeting, Los Angeles, CA, November 1997.

Carrier, R. L., Bursac, N., Vunjak-Novakovic, G., Langer, R., Rupnick, M., Freed, L. E. "Cardiac tissue engineering: influence of cell source and bioreactor conditions," poster presentation at the XIth World Congress of the International Society for Artificial Organs, Providence, RI, June 1997.

Papadaki, M., Bursac, N., Carrier, R., Langer, R., Schoen, F. J., Vunjak-Novakovic, G., Freed, L. E. "In vitro reconstitution of three-dimensional cardiac muscle: composition and functional evaluation," presented at the North Sea Biomaterials Meeting, The Hague, The Netherlands, 1998.

Papadaki, M., Bursac, N., Langer, R., Schoen, F. J., Carrier, R., Vunjak-Novakovic, G., Freed, L. E. "Engineered three-dimensional cardiac muscle: structural, biochemical, and functional assessment," presented at the American Institute of Chemical Engineers Meeting, Miami, FL, November 1998.

Bursac, N., Papadaki, M., Cohen, R. J., Schoen, F. J., Eisenberg, S. R., Carrier, R., Vunjak-Novakovic, G., Freed, L. E. "Cardiac muscle tissue engineering: an electrophysiological study," presented at the Biomedical Engineering Society meeting, Cleveland, OH, October 1998.

Freed, L. E., Bursac, N., Carrier, R., Martin, I., Papadaki, M., Vunjak-Novakovic, G. "Three-dimensional cultures of skeletal and cardiac-like tissues," presented at the American Society of Cell Biology Meeting, 1997.

top

Book Chapter

Carrier, R. L., Waterman, K. Utility of biodegradable polymers in oral drug delivery, in "Handbook of Biodegradable Polymers," edited Mallapragada, S. K., Narasimhan, B, American Scientific Publishers, 2006.

top

Patent

Billote, A. M., Carrier, R. L., Fergione, M. B., Miller, L. A., Roy, M. C., Shamblin, S. L., Waterman, K. C., MacDonald, B. C., Friesen, D. T. Osmotic pharmaceutical delivery system. PCT Int. Appl. (2003), 57 pp. WO 2003063823 A2.