The Biological Surface Engineering and Microfluidics Laboratory at Northeastern University headed by Prof. Shashi Murthy was established in January 2006.

The primary focus of our research is the use of micro- and nano-fabrication technology for biological applications. Using technology originally designed for the semiconductor industry, it is possible to design fluidic channels that have dimensions in the micron size scale or smaller.  Biological applications of these microfluidic systems have attracted considerable interest in recent years because of their ability to manipulate individual cells in carefully controlled environments.  Specific topics of interest include microfluidic cell separation systems and nanoscale probes to study cell-ligand interactions.

The second focus area of our research is the development of surface coatings for neurological implants.  Neural prostheses are a special class of implants that are under development for the treatment of various neurological disorders (such as stroke, paralysis, and Parkinson's disease). These prostheses are small, silicon-based integrated circuit devices that can send and receive electrical signals to and from neurons in the central nervous system.  An important challenge in the design of these implants is the protection of the electronic circuitry from the ambient body environment.  Another area of interest is the modification of the implant surfaces to encourage the adhesion and proliferation of neurons in order to improve the performance of the implant. Our research aims to address both of these issues by designing novel, polymeric thin films that can perform both functions.