ADDRES Lab Photo
The Advanced Drug Delivery Research (ADDRES) Laboratory at Northeastern University is headed by Dr. Rebecca Carrier of Northeastern’s Department of Chemical Engineering.

The ADDRES Lab studies transport phenomena in biological systems, with a current focus on the intestinal environment, via development of theoretical and tissue-engineered cell culture models. Computational models (molecular and macroscopic) predict what drug delivery systems will enhance absorption of a compound with specific physical and chemical properties. Macroscopic systems-based models of the intestinal drug delivery environment are in the form of mass balances and kinetic equations describing drug release, dissolution, precipitation, and absorption. Mechanistic studies are conducted to enhance fundamental understanding of these processes. Our tissue engineering focus is on developing a biomimetic scaffold with crypt-villus structure for intestinal epithelial cell culture.
Areas of Research

Computational Modelling of Intestinal Drug Delivery EnvironmentImg1
Computational modeling of the intestinal drug delivery environment to predict the influence of drug delivery agents on oral drug absorption.

Modeling and experimental studies of drug transport through intestinal mucusImg2
Modeling and experimental studies of drug transport through intestinal mucus for understanding drug-mucus interactions and how they are influenced by drug delivery agents.

Tissue engineering of intestineImg3
Tissue engineering of intestine, with a focus on understanding the influence of intestinal epithelial cell culture substrate biomimetic microtopography on cell phenotype.

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